Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An integrated approach to structural genomics.

U Heinemann1, J Frevert, K Hofmann

  • 1Forschungsgruppe Kristallographie, Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13122, Berlin, Germany. Heinemann@MDC-Berlin.de

Progress in Biophysics and Molecular Biology
|November 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Emergency room visits for asthma and the reported outcomes: The PASS survey by the CRISALIS network].

Revue des maladies respiratoires·2025
Same author

Treatment of a symptomatic cervical cerebrospinal fluid fistula after full endoscopic cervical foraminotomy with CT-guided epidural fibrin patch.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2023
Same author

The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology-First Multicenter Experience in 161 Patients.

AJNR. American journal of neuroradiology·2023
Same author

Third international challenge to model the medium- to long-range transport of radioxenon to four Comprehensive Nuclear-Test-Ban Treaty monitoring stations.

Journal of environmental radioactivity·2022
Same author

[Spontaneous intracranial hypotension with brain sagging and reversible frontotemporal dementia : Case report and review of the literature].

Der Nervenarzt·2022
Same author

[Severe adult asthma and treatment adherence: Results of the FASE-CPHG study].

Revue des maladies respiratoires·2021

Structural genomics aims to map all protein structures for homology modeling. The Protein Structure Factory (PSF) will accelerate this by analyzing human proteins using high-throughput methods.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Genomics

Background:

  • Structural genomics seeks to catalog protein structures for comprehensive biological understanding.
  • Homology modeling relies on a representative set of known protein structures.

Purpose of the Study:

  • To establish a low-cost, high-throughput infrastructure for analyzing soluble human proteins.
  • To contribute to the global effort in structural genomics.

Main Methods:

  • Expression of protein-coding genes in E. coli or yeast.
  • Semi-automated purification of affinity-tagged proteins.
  • Structure determination using X-ray diffraction and NMR spectroscopy.

Main Results:

  • Development of a robotic station for protein crystallization.

Related Experiment Videos

  • Establishment of an NMR center.
  • Creation of a synchrotron-based crystallography facility at BESSY II.

    • Conclusions:

    • The Protein Structure Factory (PSF) will enhance structural genomics efforts.
    • Automation, parallelization, and standardization are key to high-throughput structure analysis.
    • The PSF infrastructure supports comprehensive structural description of the protein universe.