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Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder
K Meszaros1, E Lenzinger, K Hornik
1University Hospital for Psychiatry, Department of General Psychiatry, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
Abstract:
Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (n=120) and patients (n=95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (P=0.056).
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