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Updated: Oct 10, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle
1Department of Oncology/Pathology, Cancer Center Karolinska, Karolinska Insitutet, 17176, Stockholm, Sweden.
Abstract:
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.
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