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Updated: Aug 10, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Genes involved in senescence and immortalization
A S Lundberg1, W C Hahn, P Gupta
1Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. Lundberg@wi.mit.edu
Current Opinion in Cell Biology
|November 7, 2000
Summary
Cellular senescence is a cell fate triggered by various stresses. Research is clarifying the roles of genes like p53 and telomere maintenance in this process and cell immortalization.
Area of Science:
- Cellular biology
- Molecular genetics
- Aging research
Background:
- Cellular senescence is a terminal cell state.
- It is induced by proliferation, oncogene activation, and oxidative stress.
Purpose of the Study:
- To elucidate the mechanisms of cellular senescence.
- To understand the role of gene regulation in senescence and immortalization.
Main Methods:
- Investigating the roles of key genes (p16INK4A, p19ARF, p53).
- Analyzing telomere maintenance in relation to immortalization.
- Studying cellular responses to various physiological stressors.
Main Results:
- Senescence is a complex cellular response.
- Specific genes and telomere dynamics are critical for regulating senescence and immortalization.
Conclusions:
- Continued research is advancing the understanding of cellular senescence.
- Mechanisms of senescence and immortalization are being progressively clarified.
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