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Hypogonadotropic hypogonadism: retrospective analysis of 19 cases
M D Moura1, P A Navarro, M F Silva de Sá
1Department of Gynecology and Obstetrics, University of São Paulo, Ribeirão Preto, Brazil. mddmoura@fmrp.usp.br
Objectives:
To survey the clinical data of patients with isolated gonadotropin deficiency.
Methods:
We retrospectively surveyed the medical records of 19 patients with isolated gonadotropin deficiency aged 16-31 years (mean: 20 years). The major complaint was primary amenorrhea in 100% of the patients, with 42.1% of them also reporting absence of secondary sex traits, and 10% reporting anosmia or hyposmia. Seventy-four percent of the patients had been submitted to hormonal replacement therapy.
Results:
Bone densitometry was determined in 5 patients and revealed lumbar spine osteopenia in 3 patients and femoral osteopenia in 1. An association with urologic malformations was detected in 10.5% of cases and an association with gynecologic malformations was detected in 31.6%.
Conclusions:
Isolated gonadotropin deficiency can be easily diagnosed but requires early estrogen replacement therapy because of a higher risk of osteopenia and consequently of osteoporosis. Concomitant urogenital malformations are frequent and should be investigated.