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Highly compressible paracetamol - II. Compression properties.

H A Garekani1, J L Ford, M H Rubinstein

  • 1School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK.

International Journal of Pharmaceutics
|November 7, 2000
PubMed
Summary
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Adding polyvinylpyrrolidone (PVP) during paracetamol crystallization significantly enhances tablet strength and compression properties. PVP-treated paracetamol shows improved tablet crushing strength and reduced elastic behavior, indicating better fragmentation during compression.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Paracetamol is a widely used analgesic and antipyretic.
  • Its poor compressibility can limit tablet formulation.
  • Crystallization additives can modify particle properties.

Purpose of the Study:

  • To investigate the effect of polyvinylpyrrolidone (PVP) on paracetamol crystallization and compression properties.
  • To evaluate the impact of PVP on tablet strength and deformation behavior.

Main Methods:

  • Paracetamol was crystallized in the presence of varying concentrations of PVP (PVP 10000 and PVP 50000).
  • Compression properties of the resulting paracetamol particles were assessed.
  • Tablet crushing strength, capping tendency, strain rate sensitivity (SRS), elastic recovery, and elastic/plastic energy (EE/PE) ratio were measured.

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Main Results:

  • Paracetamol crystallized with PVP showed significantly improved crushing strength compared to untreated paracetamol.
  • Tablets formed from PVP-treated paracetamol exhibited no capping tendency, even at high compression speeds.
  • PVP-treated particles displayed low SRS and a reduced EE/PE ratio, indicating increased fragmentation and less elastic behavior during compression.

Conclusions:

  • Crystallization of paracetamol in the presence of PVP is an effective strategy to enhance its compression properties.
  • PVP incorporation leads to more robust tablets with improved mechanical integrity.
  • The findings suggest PVP modifies paracetamol's fracture behavior, favoring plastic deformation over elastic recovery.