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Related Experiment Videos

Enhanced magnetic resonance imaging in multiple sclerosis.

M Filippi1

  • 1Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60 - 20132, Milan, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 7, 2000
PubMed
Summary

Gadolinium-enhanced MRI detects active multiple sclerosis (MS) lesions and monitors disease progression. Advanced MRI techniques improve sensitivity and understanding of lesion evolution, aiding clinical trial planning.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Neurology

Background:

  • Gadolinium-enhanced MRI is crucial for detecting active multiple sclerosis (MS) lesions.
  • It serves as a key tool for monitoring disease evolution, both naturally occurring and treatment-modified.

Purpose of the Study:

  • To review recent studies enhancing MRI sensitivity for MS disease activity.
  • To explore in vivo nature and evolution of enhancing lesions using novel MR techniques.
  • To clarify the link between enhancement and tissue loss in MS.

Main Methods:

  • Review of studies assessing enhanced MRI sensitivity for MS.
  • Investigation of non-conventional MR techniques for in vivo lesion analysis.
  • Analysis of the relationship between contrast enhancement and tissue damage.

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Main Results:

  • Enhanced MRI demonstrates high sensitivity for active MS lesions.
  • New MR techniques offer deeper insights into enhancing lesion characteristics.
  • Understanding lesion evolution aids in defining disease impact.

Conclusions:

  • Enhanced MRI is vital for MS monitoring and clinical trial management.
  • Advanced MR techniques enhance the understanding of MS pathophysiology.
  • These advancements support better planning and execution of MS clinical trials.