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Related Experiment Videos

[Neonatal hydrocephalus-volume determinations using computed tomography].

R Nakahira1, K Morimoto, O Takemoto

  • 1Department of Neurosurgery, Osaka Medical Center & Research Institute for Maternal & Child Health, Japan.

No to Shinkei = Brain and Nerve
|November 7, 2000
PubMed
Summary
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Computed tomography (CT) accurately estimates in vivo volumes. Hydrocephalic neonates show significantly larger intracranial volumes and lateral ventricle ratios compared to controls, indicating severe fluid accumulation.

Area of Science:

  • Medical Imaging
  • Pediatric Neurology
  • Neurosurgery

Background:

  • Estimating in vivo volumes noninvasively is crucial for diagnosing conditions like hydrocephalus.
  • Computed tomography (CT) presents a promising method for accurate volume assessment.
  • Neonatal brain development and volumetric changes require precise measurement techniques.

Purpose of the Study:

  • To evaluate the accuracy of CT scans in measuring in vivo cranial volumes.
  • To compare intracranial and ventricular volumes between hydrocephalic and non-hydrocephalic neonates.
  • To establish volumetric differences indicative of hydrocephalus in infants.

Main Methods:

  • Utilized contiguous 5 and 10-mm thick CT scans of phantom and neonatal crania.
  • Calculated cross-sectional areas and determined volumes using the summation-of-areas technique.

Related Experiment Videos

  • Applied an indirect intracranial volume measurement technique for comparative analysis.

    • Main Results:

    • Hydrocephalic neonates (head circumference >39 cm) exhibited 1.97 times larger intracranial volumes than controls.
    • The ratio of lateral ventricle to intracranial volume was significantly higher in hydrocephalic infants (0.57 ± 0.2) versus controls (0.0062 ± 0.001).
    • Statistical analysis confirmed a significant difference (p < 0.005) between groups.

    Conclusions:

    • CT-based volumetric analysis is a reliable method for assessing neonatal intracranial and ventricular volumes.
    • Significant volumetric discrepancies identified in hydrocephalic neonates highlight the utility of CT in diagnosis.
    • This technique aids in quantifying the extent of brain abnormalities in pediatric hydrocephalus.