Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secreted molecules in metanephric induction.

T J Carroll1, A P McMahon

  • 1Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138, USA.

Journal of the American Society of Nephrology : JASN
|November 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Measurement of Neutrino Oscillation Parameters with 10 Years of Data from the NOvA Experiment.

Physical review letters·2026
Same author

Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA.

Physical review letters·2025
Same author

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

Physical review letters·2024
Same author

Measurement of the ν_{e}-Nucleus Charged-Current Double-Differential Cross Section at ⟨E_{ν}⟩=2.4  GeV Using NOvA.

Physical review letters·2023
Same author

Functional and Behavioral Trade-Offs between Terrestrial and Aquatic Locomotion in the Amphibious Fish Kryptolebias marmoratus.

Integrative and comparative biology·2023
Same author

Search for Active-Sterile Antineutrino Mixing Using Neutral-Current Interactions with the NOvA Experiment.

Physical review letters·2021

The ureteric bud induces kidney development by signaling the nephrogenic mesenchyme. Recent findings suggest Wnt-4 is a key inducer, revising the classic model of metanephric induction.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Genetics

Background:

  • The ureteric bud's role in inducing kidney tubulogenesis was established nearly 50 years ago.
  • Identifying the specific molecular inducers of this process has been a long-standing challenge.
  • Previous research focused on a single inducer, but recent discoveries highlight the complexity of metanephric induction.

Purpose of the Study:

  • To revise the classic model of metanephric induction based on new insights into secreted molecules.
  • To re-evaluate the role of Wnt-4 as a mesenchyme-specific inducer in kidney tubulogenesis.
  • To propose a multi-event model for ureteric induction integrating growth signals.

Main Methods:

  • Review of existing literature on ureteric bud and nephrogenic mesenchyme interactions.

Related Experiment Videos

  • Analysis of recent studies on secreted molecules involved in tubulogenesis.
  • Reinterpretation of previous findings in light of new molecular data.

    • Main Results:

    • No single molecule has been identified as both necessary and sufficient for nephric induction.
    • Wnt-4 is likely a crucial mesenchyme-specific inducer involved in tubulogenesis.
    • Ureteric induction appears to involve a cascade of signals (proliferative, survival, condensation).

    Conclusions:

    • The classic model of metanephric induction requires revision.
    • Ureteric induction is a complex process involving multiple signaling events.
    • Understanding these signals is key to integrating ureteric system growth with tubulogenesis.