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Related Experiment Videos

The random-effects model applied to refractory ceramic fiber data.

L D Maxim1, J N Allshouse, D E Venturin

  • 1Everest Consulting Associates, Cranbury, New Jersey 08512, USA.

Regulatory Toxicology and Pharmacology : RTP
|November 9, 2000
PubMed
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Workplace monitoring of refractory ceramic fiber in the United States.

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Refractory ceramic fiber (RCF) workplace monitoring data from 1993-1998 were analyzed using a random-effects model. The model effectively characterized exposure variability, informing respiratory policy development and compliance criteria for this high-temperature insulating material.

Area of Science:

  • Industrial hygiene
  • Occupational health
  • Environmental science

Background:

  • Refractory ceramic fiber (RCF) is a widely used high-temperature insulator.
  • Respirable RCF fibers may pose workplace health hazards due to durability.
  • The RCF industry employs a product stewardship program (PSP) for risk management.

Purpose of the Study:

  • Analyze workplace monitoring data (1993-1998) from Unifrax plants.
  • Apply the random-effects model (REM) to RCF exposure data.
  • Evaluate criteria for occupational exposure limit compliance.

Main Methods:

  • Analysis of monitoring data collected under a U.S. EPA Consent Agreement.
  • Application of the random-effects model (REM) to log-transformed time-weighted average concentrations.

Related Experiment Videos

  • Calculation of variance components and intraclass correlations.

    • Main Results:

    • The REM demonstrated a good fit for RCF exposure data.
    • Log-transformed TWA concentration variance ranged from <0.5 to 1.0.
    • Intraclass correlations were generally low (<0.4, mostly <0.2), indicating limited between-worker variance.

    Conclusions:

    • The REM is suitable for analyzing RCF workplace exposure data.
    • Findings inform the development of workplace respiratory policies.
    • The 'overexposure' criterion is logically sound for chronic toxicants and less stringent for RCF than 'no exceedance'.