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[Meningococcemia associated with C7 deficiency].

M Ozaki1, S Bito, T Shinbo

  • 1National Tokyo Medical Center Dept. of General Internal Medicine.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|November 9, 2000
PubMed
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A young woman with meningococcemia experienced septic shock due to Neisseria meningitidis infection. Her complement C7 deficiency contributed to the severe illness, highlighting the need for early diagnosis and treatment of meningococcal disease.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Meningococcal disease, caused by Neisseria meningitidis, is rare in Japan but can rapidly progress to severe outcomes.
  • Complement deficiencies predispose individuals to invasive meningococcal infections.

Observation:

  • A 20-year-old woman presented with fever, vomiting, and rash, rapidly progressing to septic shock and disseminated intravascular coagulation (DIC).
  • Blood cultures confirmed Neisseria meningitidis (W135) infection.
  • The patient exhibited low hemolytic complement activity, with subsequent screening revealing a deficiency in the C7 complement component.

Findings:

  • The patient recovered with prompt antibiotic therapy (PCG), gabexate mesilate, and intensive care.
  • The identified complement C7 deficiency likely played a role in the severity of her meningococcal disease.

Related Experiment Videos

  • This case underscores the potential for severe meningococcal infections in individuals with complement deficiencies.

    • Implications:

    • Early recognition and management of meningococcal disease are critical, especially in patients with underlying immune deficiencies.
    • Understanding complement deficiencies is crucial for managing recurrent or severe infections.
    • This case highlights the importance of considering complement system evaluation in patients with severe meningococcal sepsis.