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Updated: Sep 4, 2026
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
[Ischemic cerebral apoplexy in children]
A Jung1, A Wagner, K V Andersen
1H:S Rigshospitalet, Juliane Marie Centeret, neuroradiologisk afdeling.
Insights
Pediatric cerebral ischemic stroke, often linked to endocarditis or trauma, can cause hemiparesis and lasting deficits in children. Early diagnosis through clinical and neuroradiological evaluation is crucial for effective management.
Area of Science:
- Pediatric Neurology
- Vascular Neurology
- Pediatric Stroke
Background:
- Cerebral ischemic stroke in children is a significant cause of acquired childhood brain injury.
- Identifying predisposing factors and clinical presentations in pediatric stroke is essential for timely diagnosis and management.
- While less common than in adults, pediatric stroke requires specific diagnostic and therapeutic approaches.
Purpose of the Study:
- To identify predisposing factors, clinical characteristics, and outcomes of cerebral ischemic stroke in children.
- To investigate the role of vascular abnormalities in pediatric ischemic stroke.
- To emphasize the importance of early clinical and neuroradiological investigations.
Main Methods:
- Retrospective case series of eight children aged 1.5-10 years diagnosed with cerebral ischemic stroke over two years.
- Clinical data collection including medical history, symptoms, predisposing factors, and neurological examination.
- Vascular imaging (e.g., angiography) to assess for arterial stenoses or occlusions.
- Review of medical records for associated conditions like infections and coagulopathies.
Main Results:
- Eight children (1.5-10 years) experienced cerebral ischemic stroke; seven were previously healthy.
- Predisposing factors included endocarditis and trauma; varicella-zoster infection preceded stroke in five children.
- Common presentation was acute hemiparesis; seven children had middle cerebral or basilar artery stenosis/occlusion.
- Five children had persistent deficits; no deaths occurred. Coagulopathies, hypertension, arteriosclerosis, and patent foramen ovale were absent.
Conclusions:
- Cerebral ischemic stroke in children can be associated with specific predisposing factors and vascular pathologies.
- Varicella-zoster infection may be a relevant preceding event in pediatric ischemic stroke.
- Prompt clinical assessment and advanced neuroimaging are critical for diagnosing pediatric ischemic stroke and guiding treatment.
Abstract:
During two years we identified eight children aged 1.5-10 years with cerebral ischaemic stroke. Prior to the stroke seven of eight children were in full health. Predisposing factors were endocarditis and trauma. Four children had prodomal symptoms prior to the infarction. All had acute hemiparesis on admission. Three of the children had fever, and five had varicellazoster infection three to 18 months prior to the stroke. Three children had convulsions. Seven of eight children had stenoses or occlusions of the middle cerebral or the basilar artery. Five children have persistent deficits and none have died. The children did not have coagulopathies, hypertension or arteriosclerosis. Echocardiography did not show patent foramen ovale. Early clinical and neuroradiological investigations are of importance in reaching the appropriate diagnosis.
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