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Permeation enhancers for transdermal drug delivery
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Drug Development and Industrial Pharmacy
|November 9, 2000
Summary
Transdermal drug delivery offers advantages like avoiding first-pass metabolism. This review classifies permeation enhancers to improve skin absorption for poorly absorbed drugs.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Dermatology
Background:
- Transdermal drug delivery is a promising route for systemic drug administration.
- Key benefits include bypassing the first-pass effect and improved patient compliance.
- A significant challenge is the skin's barrier function, limiting drug permeation.
Purpose of the Study:
- To review and classify various permeation enhancers for transdermal drug delivery.
- To elucidate the mechanisms of action of different permeation enhancers.
- To guide the selection of appropriate enhancers for enhancing percutaneous absorption of drugs.
Main Methods:
- Literature review of scientific studies on transdermal permeation enhancers.
- Classification of enhancers based on their chemical nature and/or mechanism of action.
- Analysis of reported data on the efficacy of enhancers in promoting drug permeation.
Main Results:
- Permeation enhancers are categorized based on their functional roles in overcoming skin barrier.
- Various enhancers operate through distinct mechanisms, such as altering stratum corneum lipids or intercellular pathways.
- Successful examples of enhancer application for specific drugs are discussed.
Conclusions:
- Effective selection of permeation enhancers is crucial for successful transdermal drug delivery.
- Understanding enhancer mechanisms facilitates the development of optimized transdermal formulations.
- This review provides a framework for researchers and formulators to improve transdermal drug absorption.