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Related Experiment Videos

Stability study of W/O/W viscosified multiple emulsions.

O Ozer1, V Muguet, E Roy

  • 1Ege University, Faculty of Pharmacy, Bornova-Izmir-Turkiye. ozero@eczacilik.ege.edu.tr

Drug Development and Industrial Pharmacy
|November 9, 2000
PubMed
Summary

This study formulated stable multiple emulsions using various viscosifying agents. Klucel offered superior stability, while carbomer provided better skin feel at lower concentrations, enhancing emulsion performance.

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Area of Science:

  • Cosmetic Science
  • Formulation Chemistry

Background:

  • Multiple emulsions offer unique delivery benefits but often face stability challenges.
  • Viscosifying agents are crucial for enhancing the stability and texture of emulsion formulations.

Purpose of the Study:

  • To investigate the impact of different viscosifying agents on the stability and characteristics of multiple emulsions.
  • To compare the performance of Klucel and carbomer as viscosifying agents in emulsion formulations.

Main Methods:

  • Formulation of multiple emulsions incorporating various viscosifying agents in the outer phase.
  • Assessment of macroscopic appearance, droplet size, release rate, and accelerated stability at elevated temperatures.
  • Evaluation of viscosity changes with varying concentrations of viscosifying agents.

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Main Results:

  • Increased viscosifying agent concentration led to higher viscosity.
  • Viscosifying agents significantly improved the thermal stability of the multiple emulsions.
  • Klucel-viscosified emulsions exhibited enhanced stability, while carbomer-viscosified emulsions showed improved skin feel at lower concentrations.

Conclusions:

  • The choice of viscosifying agent critically influences multiple emulsion stability and sensory properties.
  • Klucel and carbomer present distinct advantages for formulating stable and cosmetically elegant multiple emulsions.