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Related Experiment Videos

Regenerating the damaged central nervous system.

P J Horner1, F H Gage

  • 1The Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA.

Nature
|November 9, 2000
PubMed
Summary
This summary is machine-generated.

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Mammalian brain and spinal cord regeneration after injury is being reconsidered due to advances in developmental neurobiology. While promising, clear evidence for functional adult regeneration is still needed.

Area of Science:

  • Neurobiology
  • Regenerative Medicine
  • Neuroscience

Background:

  • The adult mammalian central nervous system (CNS) was long considered incapable of regeneration following injury.
  • This long-held principle is being challenged by recent scientific discoveries.

Purpose of the Study:

  • To explore the potential for regeneration in the adult mammalian brain and spinal cord.
  • To review recent advances that may facilitate CNS regeneration.

Main Methods:

  • Review of studies in developmental neurobiology.
  • Analysis of research in intracellular signaling pathways.
  • Examination of findings in neuroimmunology.

Main Results:

  • Advances in understanding brain development offer a potential blueprint for regeneration.

Related Experiment Videos

  • Progress in developmental neurobiology, intracellular signaling, and neuroimmunology are advancing the field.

    • Conclusions:

    • Recent discoveries necessitate a re-evaluation of CNS regeneration.
    • Despite progress, definitive evidence for functional adult CNS regeneration is yet to be established.