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Related Experiment Videos

Does cognitive impairment cause post-stroke depression?

Y Murata1, M Kimura, R G Robinson

  • 1Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|November 9, 2000
PubMed
Summary

Poststroke depression significantly impacts cognitive function. Improving mood in major depression after stroke leads to better cognitive recovery, suggesting depression causes impairment.

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Area of Science:

  • Neurology
  • Psychiatry
  • Cognitive Science

Background:

  • Poststroke depression is linked to cognitive impairment.
  • Previous studies failed to demonstrate cognitive improvement with mood improvement.

Purpose of the Study:

  • To investigate the causal relationship between poststroke depression and cognitive impairment.
  • To determine if mood improvement in major depression correlates with cognitive recovery.

Main Methods:

  • A consecutive series of patients with and without major depression were evaluated.
  • Cognitive functioning was assessed during acute hospitalization and at 3 or 6 months follow-up.

Main Results:

  • Patients with major depression showing mood improvement had significantly greater cognitive recovery.

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  • Cognitive improvement at follow-up was associated with greater mood improvement.

    • Conclusions:

    • Major depression following stroke appears to cause cognitive impairment.
    • Previous treatment failures may stem from including minor depression or non-responsive major depression cases.