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Familial aggregation of bronchodilator response: a community-based study.

T Niu1, J J Rogus, C Chen

  • 1Program of Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

American Journal of Respiratory and Critical Care Medicine
|November 9, 2000
PubMed
Summary
This summary is machine-generated.

Bronchodilator response (BDR) shows familial aggregation in Chinese families with asthma. Genetic factors likely play a role in BDR, influencing how individuals respond to asthma medications.

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Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Epidemiology

Background:

  • Bronchodilator response (BDR) is a key indicator in asthma management.
  • Understanding the factors influencing BDR, including genetics, is crucial for personalized treatment.
  • Familial aggregation studies can help elucidate the role of genetic versus environmental influences on respiratory traits.

Purpose of the Study:

  • To investigate the familial aggregation of bronchodilator response (BDR) in a Chinese population.
  • To explore the potential role of genetic factors in determining BDR.
  • To assess the correlation of BDR among family members in households with asthma.

Main Methods:

  • A study of 4,946 subjects from 1,161 index families with asthma in rural China.
  • BDR was measured as the percentage change in FEV(1) after albuterol administration.
  • Adjusted BDR values were analyzed for correlations between various family pairs (parents-offspring, sibling-sibling).

Main Results:

  • Significant correlations in adjusted BDR were found for father-first offspring, mother-first offspring, mother-subsequent offspring, and first-subsequent offspring pairs.
  • A modest degree of familial clustering for BDR was observed, with correlation coefficients ranging from 0.088 to 0.165.
  • Subsequent offspring with mothers and first offspring having above-median BDR showed a higher odds ratio (3.10) for familial aggregation.

Conclusions:

  • The study supports significant familial aggregation of BDR in this Chinese population.
  • These findings suggest a notable contribution of genetic factors to individual differences in BDR.
  • Further research into the genetic basis of BDR is warranted.