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Related Experiment Videos

Modulation of swallowing reflex by lung volume changes.

M Kijima1, S Isono, T Nishino

  • 1Department of Anesthesiology, Chiba University School of Medicine, Chiba, Japan.

American Journal of Respiratory and Critical Care Medicine
|November 9, 2000
PubMed
Summary

Increasing lung volume during breathing can inhibit swallowing reflexes. This study found that higher lung volumes delay swallows and disrupt their coordination with breathing phases in healthy individuals.

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Area of Science:

  • Respiratory Physiology
  • Swallowing Mechanics
  • Neuroscience

Background:

  • The coordination between respiration and swallowing is crucial for safe airway protection.
  • Understanding how respiratory changes influence swallowing is vital for clinical applications.
  • Previous research suggests a complex interplay between lung volume and the swallowing reflex.

Purpose of the Study:

  • To investigate the impact of altered lung volumes on the timing and coordination of respiration and swallowing.
  • To determine if lung inflation affects the latency and frequency of swallowing.
  • To examine the relationship between lung volume changes and the phase coupling of swallowing with respiration.

Main Methods:

  • 11 healthy subjects participated in the study.

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  • Swallowing was elicited using bolus injections and continuous infusion of distilled water.
  • Lung volume was manipulated using negative extrathoracic pressure (0, -20, -40 cm H2O).

    • Main Results:

    • Increased lung volume prolonged the latency of swallows induced by bolus injections.
    • Higher lung volumes reduced the number of swallows during continuous pharyngeal water infusion.
    • The typical coupling of swallows with the expiratory phase was disrupted under negative pressure.

    Conclusions:

    • Lung inflation appears to exert an inhibitory effect on the human swallowing reflex.
    • Altered lung volumes modulate the timing of swallowing relative to the respiratory cycle.
    • These findings have implications for understanding airway protection mechanisms during breathing variations.