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Related Experiment Videos

Corticolimbic interactions associated with performance on a short-term memory task are modified by age.

V Della-Maggiore1, A B Sekuler, C L Grady

  • 1Rotman Research Institute of Baycrest Centre, Toronto, Ontario M6A 2E1, Canada. valeria@psych.utoronto.ca

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 9, 2000
PubMed
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Aging affects memory by altering hippocampal networks. Older adults recruit different brain regions, including more anterior areas, for visual memory tasks compared to younger individuals.

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Neuroimaging

Background:

  • Aging is linked to memory decline, particularly in hippocampal functions.
  • Understanding age-related changes in brain network interactions is crucial for cognitive health.

Purpose of the Study:

  • To investigate how functional interactions between the hippocampus and cortical areas change with age.
  • To identify age-specific neural networks supporting short-term visual memory.

Main Methods:

  • Positron emission tomography (PET) was used to measure brain activity in young and old adults.
  • A delayed visual discrimination task assessed short-term memory performance.
  • Partial least squares (PLS) and structural equation modeling (SEM) analyzed functional connectivity.

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Main Results:

  • Behavioral performance on the memory task was comparable between young and old groups.
  • A distinct corticolimbic network supported memory performance in the elderly.
  • The elderly network included dorsolateral prefrontal cortex (BA 9/46) and caudate nucleus, differing from the young group's network (BA 10, fusiform gyrus).

Conclusions:

  • Age-related cognitive changes involve modifications in large-scale brain network operations, not just focal changes.
  • The elderly recruit different, more anterior brain regions for visual memory, suggesting compensatory mechanisms.