Evolutionary relationships among proteins encoded by the regulator of complement activation gene cluster

J Krushkal1, O Bat, I Gigli

  • 1Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609-2280, USA. krushkal@wpi.edu

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...