Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estradiol levels in psychotic disorders.

T J Huber1, J Rollnik, J Wilhelms

  • 1Department of Clinical Psychiatry and Psychotherapy, Medical School of Hannover, Carl-Neuberg-Strasse 1, 30623, Hannover, Germany. t.j.huber@gmx.de

Psychoneuroendocrinology
|November 9, 2000
PubMed
Summary

Women with psychotic disorders, including schizophrenia, show lower estradiol levels, potentially increasing psychosis risk during low estrogen phases. Hospitalization stress may also affect hormone levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Prolonged Weaning - S2k-Guideline Published by the German Respiratory Society].

Pneumologie (Stuttgart, Germany)·2019
Same author

Combination therapy with nefazodone and lithium: Safety and tolerability in fourteen patients.

International journal of psychiatry in clinical practice·2014
Same author

[Dronabinol in neuropsychiatric diseases].

Schmerz (Berlin, Germany)·2013
Same author

Inside a synesthete's head: a functional connectivity analysis with grapheme-color synesthetes.

Neuropsychologia·2012
Same author

Naturalistic pharmacotherapy of acute episodes of schizophrenic disorders in comparison to treatment guidelines.

Pharmacopsychiatry·2012
Same author

Disinhibited feedback as a cause of synesthesia: evidence from a functional connectivity study on auditory-visual synesthetes.

Neuropsychologia·2012

Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Reproductive Endocrinology

Background:

  • Estradiol is theorized as a protective factor against psychosis, particularly in women.
  • Schizophrenia patients often exhibit lower estradiol levels and psychosis onset during low estrogen phases.

Purpose of the Study:

  • To investigate estradiol levels in women with acute psychotic episodes.
  • To confirm the association between low estradiol and psychosis in schizophrenia and other psychotic disorders.

Main Methods:

  • An open prospective study involving 43 women admitted with acute psychotic episodes.
  • Estradiol and progesterone levels were measured and compared to healthy controls and patients with other psychiatric diagnoses.

Main Results:

Related Experiment Videos

  • Women with acute psychosis had significantly lower estradiol levels than healthy controls.
  • Only 28% of psychotic patients were in a peri- or postovulatory phase; most had low or below-normal estradiol.
  • Patients with other psychiatric diagnoses showed intermediate estradiol levels, not significantly different from either group.

Conclusions:

  • Low estradiol levels are confirmed in women with acute psychotic disorders.
  • Hypothalamic downregulation due to hospitalization stress is a potential confounding factor in hormone level assessment.
  • Further research is needed to clarify the role of estradiol in psychosis and the impact of stress on hormone levels.