Related Experiment Video
Updated: Jul 31, 2026

A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
Published on: April 12, 2019
Pergolide-induced dyspnea, bilateral pleural effusion and peripheral edema
S Varsano1, M Gershman, E Hamaoui
1Department of Pulmonary Medicine, Sapir Medical Center, Meir General Hospital, Kfar Sava and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. varsanos@bezeqint.net
Abstract:
A patient with severe Parkinson's disease presented with increasing dyspnea, bilateral pleural effusion and peripheral edema that were refractory to diuretic therapy and were first misdiagnosed as signs of right-sided heart failure. Pergolide was the only culprit for this devastating condition and on its discontinuation all signs of fluid retention resolved. In this report, drug reactions to ergots and dopamine agonists are discussed.
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