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[Nose bleeds and nitric oxide in the nose]
K Kaneko1, T Shimanuki, T Komoda
1Department of Otorhinolaryngology, Saitama Medical School.
Nihon Jibiinkoka Gakkai Kaiho
|November 9, 2000
Summary
Nosebleeds are linked to lower nitric oxide (NO) production, potentially caused by oxidative stress and hypertension. Reduced NO may exacerbate blood pressure issues, contributing to recurrent nosebleeds.
Area of Science:
- Otorhinolaryngology
- Biochemistry
- Physiology
Context:
- Nitric oxide (NO) produced in the nasal passages is crucial for respiratory health.
- Nasal allergies are frequently associated with NO levels.
- The relationship between nosebleeds, oxidative stress, and NO requires further investigation.
Purpose:
- To investigate the potential link between nosebleeds and reactive oxygen species.
- To evaluate nitric oxide synthase (NOS) expression in nasal mucosa.
- To measure NO concentration in exhaled nasal air and superoxide dismutase activity.
Summary:
- Lower inducible nitric oxide synthase (iNOS) expression was observed in subjects with nosebleeds compared to controls.
- Nosebleed subjects exhibited significantly lower NO concentrations in exhaled nasal air.
- Serum superoxide dismutase levels were significantly elevated in subjects experiencing nosebleeds.
Impact:
- Findings suggest reduced NO production in nosebleed subjects, possibly exacerbated by pre-existing hypertension and oxidative stress.
- This reduction in NO may contribute to elevated blood pressure and subsequent nasal vessel rupture.
- Increased superoxide dismutase activity indicates a response to high superoxide anion concentrations during nosebleeds.