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[Prostate-specific antigen].

I A Eide1, A Angelsen

  • 1Institutt for abdominale fag, Det medisinske fakultet, Norges teknisk-naturvitenskapelige universitet, Trondheim.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|November 9, 2000
PubMed
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Serum prostate-specific antigen (PSA) is a key tumor marker for prostate cancer detection. Understanding its limitations and utilizing newer methods can improve diagnostic accuracy for this common cancer.

Area of Science:

  • Urology
  • Oncology
  • Biochemistry

Context:

  • Serum PSA has been a vital tumor marker for prostate cancer for over a decade.
  • Its clinical utility and limitations in diagnosing prostate cancer require careful consideration.

Purpose:

  • To review the clinical usefulness and limitations of serum PSA as a prostate cancer tumor marker.
  • To explore advancements in PSA testing for improved prostate cancer detection.

Summary:

  • Elevated serum PSA (≥4.0 ng/ml) can indicate prostate cancer, but benign prostatic hyperplasia is a common cause of elevation.
  • Newer methods like age-specific PSA, PSA velocity, PSA density, and free PSA percentage aim to enhance sensitivity and specificity.
  • While PSA is the best available tumor marker, awareness of its limitations is crucial for clinicians.

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Impact:

  • Improved understanding of PSA test interpretation in clinical practice.
  • Potential for more accurate prostate cancer diagnosis through combined or refined PSA testing methods.
  • Highlights the importance of ongoing research in cancer biomarker development.