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A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

Bacterial colonisation and infection in lesions of the central nervous system

P A Raine, D G Young

    Developmental Medicine and Child Neurology. Supplement
    |January 1, 1975
    PubMed

    Insights

    Bacterial colonization patterns in newborn infants with spina bifida significantly correlate with infection development. Understanding these patterns is crucial for managing infections in vulnerable newborns.

    Area of Science:

    • Medical Microbiology
    • Neonatalogy
    • Pediatric Surgery

    Background:

    • Newborn infants with spina bifida are susceptible to bacterial colonization and infection.
    • Early-life microbial patterns influence health outcomes in neonates.

    Purpose of the Study:

    • To investigate bacterial colonization patterns in the first month of life among infants with spina bifida.
    • To determine the relationship between colonization and subsequent infection episodes.

    Main Methods:

    • Prospective study of 116 newborn infants diagnosed with spina bifida.
    • Monitoring of bacterial colonization and identification of infective episodes.
    • Correlation analysis between colonizing and infecting microorganisms.

    Main Results:

    • Bacterial colonization correlated with infection in over 75% of 90 infective episodes.
    • Primary infection sites included the spina bifida lesion, ventricles, and urinary tract.
    • Infection was a significant cause of mortality, accounting for 27 of 35 deaths.

    Conclusions:

    • Bacterial colonization patterns are closely linked to infection development in newborns with spina bifida.
    • Identifying colonization factors can aid in preventing serious infections and improving outcomes.
    • Targeted interventions may reduce infection-related mortality in this high-risk population.

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