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Visual evoked potentials in cerebral white matter hyperintensity on MRI
1Department of Neurology, Neurological Institute, Tokyo Women's Medical University, Japan. br7k-sbt@asahi-net.or.jp
Acta Neurologica Scandinavica
|November 9, 2000
Summary
Cerebral white matter hyperintensities (WMH) significantly impact visual evoked potentials (VEPs) in elderly individuals. VEP measures like P100 latency and amplitude are influenced by WMH location and gender.
Area of Science:
- Neuroscience
- Ophthalmology
- Radiology
Background:
- Cerebral white matter hyperintensities (WMH) are common in elderly individuals.
- WMH can affect neurological function, including visual pathways.
- Visual evoked potentials (VEPs) assess the integrity of the visual pathway.
Purpose of the Study:
- To investigate the correlation between cerebral white matter hyperintensities (WMH) and visual evoked potentials (VEPs) in elderly subjects.
- To analyze how the location and characteristics of WMH influence VEP parameters.
Main Methods:
- Pattern VEP (PVEP) and flash VEP (FVEP) were recorded.
- 25 patients with WMH (12 frontal dominant, 13 occipital dominant) and 25 with basal ganglionic hyperintensities (BGH) were studied.
- Controls were included for comparison.
Main Results:
- Subjects with WMH showed significantly larger P100 and P2 amplitudes compared to BGH and controls.
- Occipital dominant WMH (OMH) exhibited larger P100 amplitudes than frontal dominant WMH (FMH).
- In OMH, males had prolonged P100 latency, while females showed larger P100 and P2 amplitudes compared to males.
Conclusions:
- WMH significantly alter VEP measures in elderly individuals.
- VEP interpretation requires consideration of WMH presence, location, and gender.
- Clinical VEP values should account for WMH, gender, and age-related changes.