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Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration
D C Shields1, N G Avgeropoulos, N L Banik
1Department of Neurology, Medical University of South Carolina, Charleston 29425, USA.
Neurochemical Research
|November 9, 2000
Abstract:
In this study, we examine the clinical, neuroradiological, and immunohistochemical findings of a 51 year old white female who died 27 months after onset of acute multiple sclerosis despite treatment with interferon-beta, azathioprine, corticosteroids, and cyclophosphamide. Immunohistochemical studies revealed extensive gliosis and mononuclear phagocyte infiltration with corresponding upregulation of proinflammatory cytokines (eg. IFN-alpha, TNF-alpha). The significance of immunohistochemical findings with respect to clinical presentation is discussed.