Delayed transient neurologic toxicity due to tacrolimus: CT and MRI

Area of Science:

• Neurology
• Pharmacology
• Transplantation

Background:

• Tacrolimus is a calcineurin inhibitor immunosuppressant commonly used post-transplant.
• Neurological toxicity is a potential, though not fully understood, adverse effect of tacrolimus.

Observation:

• A patient developed transient neurologic symptoms after a bone-marrow transplant.
• Clinical presentation and imaging studies were consistent with neurotoxicity.

Findings:

• Symptoms showed complete regression upon cessation of tacrolimus therapy.
• The case highlights a reversible neurological adverse event linked to tacrolimus.

Implications:

• Understanding tacrolimus-induced neurotoxicity is crucial for managing transplant patients.
• This case may inform the differential diagnosis of neurologic symptoms in immunosuppressed individuals.
• Further research into the mechanisms of immunosuppressant-related neurotoxicity is warranted.