Distribution and possible functional roles of some neuroactive peptides in the mammalian superior olivary complex

The mammalian superior olivary complex (SOC) is innervated by neuronal systems that contain a variety of neuroactive peptides. Conversely, neurones of the SOC form peptidergic projections to other targets. In this review, the peptides substance P, calcitonin-gene-related peptide, enkephalins and dynorphins, cholecystokinin and somatostatin are considered. Their distribution in fibres and cell bodies of the SOC are considered, with particular attention to differences between the SOC subdivisions. Evidence for the functional effects of these peptides is also reviewed and some brief speculations are offered about their possible functional role in hearing.