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Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene
J N Schofield1, T W Rademacher
1Molecular Medicine Unit, Department of Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland Street, W1P 6DB, London, UK.
Biochimica Et Biophysica Acta
|November 10, 2000
Abstract:
Here we report the structure of the human glycosylphosphatidylinositol phospholipase D1 gene, which covers at least 80 kb on chromosome 6p22. The gene comprises 25 exons and encodes a 5.8 kb mRNA, which was detected only in the liver. Southern blot analysis shows that the human genome contains only one GPLD gene and we could only detect one of the two previously reported cDNAs.