Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel method for the transport and long-term storage of cultures and samples in an anaerobic atmosphere.

Letters in applied microbiology·2018
Same author

Prospects for RNA delivery with nanotechnologies.

Gene therapy·2017
Same author

Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: Targetable nanocomplexes for in vivo nucleic acid delivery.

Acta biomaterialia·2017
Same author

A critical role for ATF2 transcription factor in the regulation of E-selectin expression in response to non-endotoxin components of Neisseria meningitidis.

Cellular microbiology·2015
Same author

Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA.

Gene therapy·2013
Same author

Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI.

Analytical and bioanalytical chemistry·2012

Related Experiment Video

Updated: Jul 27, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Adhesion molecules and gene transfer.

R J Parkes1, S L Hart

  • 1Molecular Immunology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Advanced Drug Delivery Reviews
|November 10, 2000
PubMed
Summary

Cell adhesion molecules mediate cell interactions and are exploited by pathogens. Researchers are developing gene and drug delivery systems using these molecules for targeted uptake, offering potential advantages.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Biotechnology

Background:

  • Cell adhesion molecules (CAMs) are crucial for cell-cell and cell-extracellular matrix (ECM) interactions.
  • Pathogenic microorganisms utilize CAMs as entry receptors, a phenomenon exploited in biomedical research.
  • Understanding CAMs' role in pathogen entry informs novel therapeutic strategies.

Purpose of the Study:

  • To review the development of gene and drug delivery systems targeting cell adhesion molecules.
  • To explore the potential advantages of CAM-targeted delivery over other receptor-targeted systems.

Main Methods:

  • Literature review of research on cell adhesion molecules in pathogen entry and drug/gene delivery.
  • Analysis of studies developing and evaluating CAM-targeted delivery systems.

More Related Videos

Expression of Fluorescent Fusion Proteins in Murine Bone Marrow-derived Dendritic Cells and Macrophages
09:07

Expression of Fluorescent Fusion Proteins in Murine Bone Marrow-derived Dendritic Cells and Macrophages

Published on: October 30, 2018

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors
06:41

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jul 27, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Expression of Fluorescent Fusion Proteins in Murine Bone Marrow-derived Dendritic Cells and Macrophages
09:07

Expression of Fluorescent Fusion Proteins in Murine Bone Marrow-derived Dendritic Cells and Macrophages

Published on: October 30, 2018

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors
06:41

Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors

Published on: October 20, 2023

  • Comparison of CAM-targeted systems with alternative receptor-targeted delivery approaches.

    • Main Results:

    • Cell adhesion molecules serve as natural targets for pathogen entry.
    • Significant research efforts are focused on utilizing CAMs for targeted gene and drug delivery.
    • CAM-targeted systems show promise for enhanced therapeutic efficacy and specificity.

    Conclusions:

    • Cell adhesion molecules represent a promising target for advanced drug and gene delivery systems.
    • Exploiting CAMs offers potential advantages in targeting and cellular uptake compared to other methods.
    • Further research in this area could lead to innovative therapeutic solutions.