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Updated: Jul 24, 2026
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
Pancreatic tumors show high levels of hypoxia
1Department Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA. akoong@cmgm.stanford.edu
Purpose:
Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.
Methods And Materials:
Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.
Results:
All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.
Conclusion:
Tumor hypoxia exists within pancreatic cancers.
