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Updated: Aug 14, 2026

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
Published on: April 4, 2016
On the Reconstruction of Ancient Doubled Circular Genomes Using Minimum Reversals
Abstract:
We propose a model of the doubling of a bacterial genome followed by gene order rearrangement to explain present-day patterns of duplicated genes. On the hypothesis that inversion (reversal) is the predominant mechanism of rearrangement, we ask how to reconstruct the ancestral genome at the moment of genome duplication. We present a polynomial algorithm for finding such a genome that minimizes (within 2 reversals) the Hannenhalli-Pevzner formula for reversal distance from the modern genome. We illustrate by applying the algorithm to a set of duplicate genes in the Marchantia polymorpha mitochondrial genome.
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