[POEM syndrome].

Area of Science:

• Hematology
• Neurology
• Endocrinology

Context:

• POEMS syndrome is a rare multisystemic disorder.
• It involves plasma cell dyscrasia, distinct from multiple myeloma.
• Characterized by a specific constellation of clinical, radiological, and laboratory findings.

Purpose:

• To summarize the clinical, radiological, and laboratory features of POEMS syndrome.
• To differentiate POEMS syndrome from other plasma cell dyscrasias.
• To highlight the potential role of cytokines in its pathogenesis.

Summary:

• POEMS syndrome presents with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes.
• Additional common manifestations include edema, arteriopathy, nephropathy, thrombocytosis, and osteosclerotic lesions.
• Pathogenesis may involve synergistic pleiotropic cytokines affecting multiple systems.

Impact:

• Provides a comprehensive overview for clinicians and researchers.
• Aids in the diagnosis and understanding of this rare syndrome.
• Informs potential therapeutic strategies targeting cytokine pathways.