Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Genetics of migraine].

A Ducros1

  • 1Service de neurologie, hôpital Lariboisière, Paris, France.

Pathologie-Biologie
|November 10, 2000
PubMed
Summary

Migraine is hereditary, likely polygenic. Familial hemiplegic migraine, with clear inheritance, helps identify genes like CACNA1A for common migraine forms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Migraine management in France: Practices of general practitioners and neurologists.

Revue neurologique·2025
Same author

Migraine treatment: Position paper of the French Headache Society.

Revue neurologique·2024
Same author

Silent brain infarct in migraine: Systematic review and meta-analysis.

Revue neurologique·2023
Same author

Foreword.

Revue neurologique·2021
Same author

Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 3: Non-pharmacological treatment.

Revue neurologique·2021
Same author

Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 2: Pharmacological treatment.

Revue neurologique·2021

Area of Science:

  • Genetics
  • Neurology

Context:

  • Migraine with or without aura is recognized as a hereditary neurological condition.
  • Most common migraine forms exhibit complex polygenic inheritance patterns, complicating genetic research.
  • Familial hemiplegic migraine (FHM) presents a unique Mendelian, autosomal dominant inheritance, offering a distinct research avenue.

Purpose:

  • To leverage FHM's distinct inheritance pattern to identify strong candidate genes for migraine.
  • To investigate the genetic underpinnings of both rare and common migraine subtypes.
  • To explore the role of identified genes in the broader migraine population.

Summary:

  • Two family studies confirm migraine's hereditary nature, with polygenic transmission likely for common types.
  • FHM, an autosomal dominant migraine, has implicated the CACNA1A gene (P/Q type calcium channels) in 50% of cases, and two other loci in 20% and remaining families.
  • Further research is needed to understand CACNA1A mutation mechanisms, identify other FHM genes, and clarify their role in common migraines.

Impact:

  • Identification of FHM genes provides crucial insights into migraine pathophysiology.
  • Understanding genetic factors in FHM can inform diagnostic strategies and therapeutic targets for all migraine types.
  • This research paves the way for targeted genetic therapies and personalized medicine approaches for migraine sufferers.

Related Experiment Videos