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Disposition of olanzapine in Chinese schizophrenic patients
H Y Lane1, H C Liu, C M VanDenBerg
1Department of Psychiatry, Tzu-Chi General Hospital and Tzu-Chi University, Hualien, Taiwan.
Abstract:
The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (+/- SD) oral clearance and elimination half-life of olanzapine were 51.5+/-61.6 l/h and 30.9+/-4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.
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