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Assessment of a genetic contribution to osteoarthritis of the hip: sibling study

P Lanyon1, K Muir, S Doherty

  • 1Clinical Immunology Unit, Queens Medical Centre, Nottingham NG7 2UH, UK.

BMJ (Clinical Research Ed.)
|November 10, 2000
PubMed
Abstract

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...