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Synthesis and deprotection of oligonucleotides under aprotic conditions
1Department of Chemistry, Colorado State University, Ft. Collins, Colorado 80523, USA.
Organic Letters
|November 14, 2000
Abstract:
Oligonucleotides containing an alkali-labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine-protecting groups is an integral component of this approach.