Related Experiment Videos
Dehydropeptides from orthogonal ligation of unprotected peptides
1Department of Microbiology and Immunology, Vanderbilt University, A 5119 MCN, Nashville, Tennessee 37323, USA.
Organic Letters
|November 14, 2000
Abstract:
A facile method has been developed to synthesize linear and cyclic dehydropeptides from unprotected peptide precursors. This method exploits an N-terminal Cys for a Cys-thioester ligation to generate an unprotected peptide and as a precursor for conversion to DeltaAla by beta-elimination under mild conditions.