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Ethylamine in human urine.

S C Mitchell1, A Q Zhang, R L Smith

  • 1Molecular Toxicology, Division of Biomedical Sciences, Sir Alexander Fleming Building, Imperial College School of Medicine, South Kensington, SW72AZ, London, UK.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 14, 2000
PubMed
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Urinary ethylamine excretion was measured in 200 healthy adults. Tea consumption was found to increase ethylamine levels, though no other major dietary sources were identified.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Ethylamine is a biogenic amine with largely unknown physiological roles.
  • Understanding its excretion patterns is crucial for metabolic and toxicological assessments.

Purpose of the Study:

  • To quantify the daily urinary excretion of ethylamine in a healthy human population.
  • To investigate potential dietary influences on ethylamine excretion levels.

Main Methods:

  • Measurement of urinary ethylamine output in 200 healthy volunteers (100 male, 100 female) under normal dietary conditions.
  • Analysis of 41 food substances to identify dietary sources of ethylamine.

Main Results:

  • The average daily urinary ethylamine excretion was 7.82 ± 7.03 mg, with a wide range (0.22–35.27 mg).

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  • No significant dietary sources were identified, with the notable exception that tea consumption led to increased urinary ethylamine.
  • No substantial differences were observed between male and female excretion levels.

    • Conclusions:

    • Urinary ethylamine excretion exhibits significant inter-individual variability in healthy adults.
    • Dietary factors, particularly tea consumption, can influence ethylamine excretion.
    • Further research is warranted to elucidate the metabolic pathways and physiological significance of ethylamine.