Related Experiment Video
Updated: Sep 18, 2026

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors
Published on: January 21, 2017
Post-traumatic meningitis: histomorphological findings, postmortem microbiology and forensic implications
1Institute of Legal Medicine, University of Hamburg, Butenfeld 34, D-22529, Hamburg, Germany.
Abstract:
Infections of the leptomeninges with the infectious agent gaining access to the intracranial compartment by traumatic means are termed post-traumatic. In cases with fatal outcome, the manner of death has to be classified as non-natural. Six cases of post-traumatic meningitis as the cause of death from the archives of the Institute of Legal Medicine in Hamburg, Germany with histological and microbiological investigations are presented. There were all males, age varying between 24 and 90 years (mean 58 years); range of the interval between original trauma and beginning of symptoms was 2 days up to 8 years; in 50% of the cases meningeal swabs yielded Streptococcus pneumoniae. Findings concerning origin and mechanism of post-traumatic meningitis as well as microbiological studies are compared with selected cases from the literature.
Insights
Post-traumatic meningitis, an infection of the brain
Area of Science:
- Forensic Pathology
- Infectious Diseases
- Neurology
Background:
- Post-traumatic meningitis results from infections entering the intracranial compartment via trauma.
- Fatal cases necessitate classification as non-natural deaths.
Observation:
- This study presents six fatal cases of post-traumatic meningitis from the Institute of Legal Medicine in Hamburg.
- All cases involved males aged 24-90 years (mean 58).
- The interval between trauma and symptom onset ranged from 2 days to 8 years.
Findings:
- Streptococcus pneumoniae was identified in 50% of meningeal swab samples.
- The study details the origin and mechanisms of post-traumatic meningitis.
- Microbiological findings are compared with existing literature.
Implications:
- Understanding post-traumatic meningitis is crucial for forensic investigations.
- Histological and microbiological data aid in determining cause of death.
- This research contributes to the knowledge of traumatic brain injury complications.
More Related Videos
07:26Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
Published on: July 1, 2018
07:59Integrated Protocol for Assessing Meningeal Lymphatics: Cisterna Magna Injection, Lymph Node Imaging, Meningeal Dissection, and Whole-Mount Staining
Published on: May 29, 2026
Related Concept Videos
Bacterial Meningitis
Viral Meningitis
Cryptococcal Meningitis
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Brain Abscess l: Introduction