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Related Experiment Videos

Age-dependent changes in sensitivity to antigen: its relationship with the antigen processing system.

B G Carter, E S Rector

    Journal of Immunology (Baltimore, Md. : 1950)
    |January 1, 1976
    PubMed
    Summary
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    Mice antibody production improves with age due to increased immune cell diversity, not changes in antigen processing. Neonatal mice show narrower antibody response curves compared to adults.

    Area of Science:

    • Immunology
    • Developmental Biology

    Background:

    • Antibody production capability matures with age.
    • Antigen processing and accessory cell systems play a role in immune responses.

    Purpose of the Study:

    • To investigate the relationship between the antigen processing system and the age-related maturation of antibody production.
    • To compare antibody responses in neonatal and adult mice within an identical antigen-processing environment.

    Main Methods:

    • Analyzing IgM and IgG2a antibody-forming cell (PFC) responses in neonatal and adult mouse spleen cells.
    • Challenging spleen cells with varying sheep red blood cell (SRC) numbers in irradiated syngeneic recipients.
    • Examining antigen dose-antibody response curves and bandwidths.

    Main Results:

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    • Optimal antigen dose for antibody response was similar between neonatal and adult mice in the standardized system.
    • Antibody response curves were narrower in neonatal mice compared to adult mice.
    • Adult spleens had a higher frequency of accessory cells for IgG responses than neonatal spleens.

    Conclusions:

    • Maturation of the antigen-processing system increases sensitivity to antigen.
    • Increased antibody response bandwidth with age is attributed to greater diversity in immunocompetent cells.
    • The antigen-processing system itself does not explain the age-related differences in response bandwidth.