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Experimental cutaneous candidiasis in rodents.

T L Ray, K D Wuepper

    The Journal of Investigative Dermatology
    |January 1, 1976
    PubMed
    Summary
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    Viable Candida albicans applied to newborn rodent skin caused microabscesses, demonstrating a new animal model for cutaneous candidiasis research. This model helps study fungal infections and neutrophil responses.

    Area of Science:

    • Mycology
    • Dermatology
    • Immunology

    Background:

    • Cutaneous candidiasis is a common fungal infection.
    • Understanding the pathogenesis of skin infections is crucial.
    • Existing models may lack specific features for studying Candida skin infections.

    Purpose of the Study:

    • To develop and characterize a novel animal model for cutaneous candidiasis.
    • To investigate the role of viable Candida species in inducing skin lesions.
    • To establish a controllable model for studying host responses to fungal skin pathogens.

    Main Methods:

    • Epicutaneous application of viable Candida albicans and Candida stellatoidea to newborn rats and mice under occlusion.
    • Evaluation of epidermal micropustules and subcorneal microabscesses.

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  • Microscopic examination using periodic acid-Schiff staining to identify Candida pseudohyphae.

    • Main Results:

    • Viable Candida albicans and C. stellatoidea induced subcorneal microabscesses in newborn rodents.
    • Heat-killed Candida or occlusion alone did not cause micropustules.
    • Lesion formation was dependent on the number of organisms and duration of application.
    • Candida pseudohyphae were observed penetrating the epidermis.

    Conclusions:

    • A reproducible animal model for cutaneous candidiasis was established using viable Candida species.
    • This model allows for controlled investigation of fungal skin infections.
    • The model is suitable for studying factors influencing neutrophil accumulation in the epidermis during candidiasis.