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Updated: Aug 10, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Metastatic hepatocellular carcinoma to the heart
1Department of Surgical Pathology, Stanford Medical Center, Stanford, California 94305, USA. katkins@yahoo.com
Insights
Hepatocellular carcinoma rarely affects the heart. This case highlights key cytologic features for diagnosing cardiac tumors, even when the primary cancer is unknown.
Area of Science:
- Cardiovascular Pathology
- Hepatobiliary Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver malignancy.
- Cardiac involvement by HCC is exceptionally rare, posing diagnostic challenges.
Observation:
- A case of right ventricular heart mass is presented.
- The mass was cytologically diagnosed as hepatocellular carcinoma.
- Classic HCC cytologic features were identified, including trabecular patterns, endothelial cells, and intracytoplasmic hyaline bodies.
Findings:
- The tumor exhibited characteristic hepatocellular carcinoma cytology.
- Differential diagnosis for cardiac tumors was discussed.
- The patient survived surgical removal of the cardiac mass, with residual disease.
Implications:
- This case underscores the importance of considering HCC in cardiac masses, especially in patients with unknown primary tumors.
- Cytologic evaluation is crucial for accurate diagnosis and appropriate patient management.
- Further research into rare metastatic patterns of HCC is warranted.
Abstract:
Right ventricular heart involvement of an otherwise unknown hepatocellular carcinoma is presented and the cytologic differential diagnosis is discussed. This tumor displays classic cytologic features of hepatocellular carcinoma, including trabecular arrangements with prominent endothelial cells and numerous intracytoplasmic hyaline bodies. The background contains many "naked nuclei" and extracellular hyaline bodies. The patient is alive with residual disease 4 months after surgical extirpation of the cardiac mass.
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