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Autoimmune progesterone urticaria.

C Vasconcelos¹, P Xavier, A P Vieira

¹Department of Dermatology and Venereology, University Hospital of São João, Porto, Portugal.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology

|November 15, 2000

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Autoimmune progesterone dermatitis causes cyclic skin rashes. Oophorectomy completely resolved a patient's severe autoimmune progesterone urticaria, indicating its effectiveness.

Area of Science:

Dermatology
Immunology
Endocrinology

Background:

Autoimmune progesterone dermatitis is a rare condition causing cyclic skin eruptions.
These reactions typically occur during the luteal phase of the menstrual cycle.

Observation:

A 47-year-old woman presented with autoimmune progesterone urticaria.
Intradermal testing showed a significant allergic reaction to progesterone.

Findings:

Initial treatment with tamoxifen and leuprolide acetate provided only partial symptom relief.
Surgical removal of the ovaries (bilateral oophorectomy) resulted in complete resolution of the skin lesions.

Implications:

This case highlights oophorectomy as a definitive treatment for severe autoimmune progesterone urticaria.

Related Experiment Videos

Understanding progesterone's role in immune-mediated skin conditions is crucial for developing targeted therapies.