[A case of high dose administration of propofol]

A 34 year-old-man was scheduled for clipping and bypass surgery of dissecting aneurysm of the right vertebral artery. He previously had an episode suggesting malignant hyperthermia susceptibility during anesthesia managed with suxamethonium and isoflurane. Before the present operation, oral dantrolene 200 mg was administered. Anesthesia was induced with 120 mg of propofol and maintained with 10-6 mg.kg-1.hr-1 of propofol and 60 micrograms.hr-1 of fentanyl for 24 hours. Total dose of propofol amounted to 9,900 mg. Because propofol is formulated as a 10% oil in water emulsion, its high dose administration could alter serum lipid concentrations. However postoperative triglyceride and cholesterol concentrations remained within normal ranges in our case.