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Multidrug-resistant typhoid fever.

S K Kabra1, Madhulika, A Talati

  • 1VS General Hospital, Ellis Bridge, Ahmedabad, Gujarat, India.

Tropical Doctor
|November 15, 2000
PubMed
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This study on Salmonella typhi in children found high resistance to common antibiotics. Ciprofloxacin and ceftriaxone were effective against multidrug-resistant typhoid, leading to faster recovery and fewer complications.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Typhoid fever, caused by Salmonella Typhi, remains a significant pediatric health concern globally.
  • Emerging antibiotic resistance poses a therapeutic challenge in managing typhoid fever.

Purpose of the Study:

  • To investigate the clinical profile and complications of Salmonella Typhi infections in children.
  • To evaluate antibiotic susceptibility patterns and treatment outcomes in pediatric typhoid fever.

Main Methods:

  • A prospective study of 100 children with confirmed Salmonella Typhi bacteremia.
  • Clinical data collection, Widal testing, antibiotic susceptibility testing, and complication monitoring were performed.

Main Results:

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  • Fever, vomiting, and abdominal pain were the most common clinical features.
  • High resistance rates (80%) were observed for amoxicillin, chloramphenicol, and co-trimoxazole.
  • Ciprofloxacin and ceftriaxone demonstrated excellent sensitivity.
  • Complications, including encephalopathy and gastrointestinal bleeding, were more frequent with multidrug-resistant strains.
  • Ciprofloxacin and ceftriaxone led to the shortest defervescence times.

    • Conclusions:

    • Multidrug-resistant Salmonella Typhi is prevalent in pediatric cases.
    • Ciprofloxacin and ceftriaxone are effective treatment options for pediatric typhoid fever.
    • Prompt and appropriate antibiotic selection is crucial for managing complications and improving outcomes.