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Perinatal asphyxia: multivariate analysis of risk factors
T Kolatat1, N Vanprapar, W Thitadilok
1Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|November 15, 2000
Summary
Perinatal asphyxia is a major cause of newborn death. Low birth weight is a significant risk factor, highlighting the need for specialized neonatal resuscitation for vulnerable infants in resource-limited settings.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Public Health
Background:
- Perinatal asphyxia significantly contributes to neonatal mortality and morbidity.
- Risk assessment for perinatal asphyxia is crucial in developing countries due to high birth rates and limited resources.
Purpose of the Study:
- To determine the incidence of perinatal asphyxia.
- To identify risk factors for perinatal asphyxia in infants born to high-risk mothers.
Main Methods:
- A prospective study was conducted over five years (1993-1997) at a tertiary referral hospital.
- 961 infants from 878 high-risk mothers were recruited.
- Univariate and stepwise multiple logistic regression analyses were used to identify significant risk factors.
Main Results:
- The incidence of perinatal asphyxia was 9.7%, with the highest rate (26.7%) observed in infants weighing less than 1000g.
- Common risk factors included abnormal fetal heart rate, meconium-stained amniotic fluid, and premature delivery.
- Stepwise multiple logistic regression identified low birth weight as the only significant independent risk factor associated with perinatal asphyxia.
Conclusions:
- Neonatal resuscitation teams are essential for very low birth weight infants.
- Premature and breech deliveries require specialized attention in resource-limited settings to mitigate risks associated with perinatal asphyxia.