Related Experiment Video
Updated: Jul 23, 2026

10:17
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Why genes don't count (for racial differences in health).
1US Southwest and Mexico Program, School of Natural Science, Hampshire College, Amherst, MA 01002, USA. agoodman@hampshire.edu
American Journal of Public Health
|November 15, 2000
Summary
Race is not a valid biological concept, as human genetic variation is continuous and complex. Using race to explain genetic or disease differences relies on disproven assumptions and limits understanding of social factors impacting health.
Area of Science:
- Genetics
- Sociology
- Anthropology
Background:
- Genetic data historically supported the concept of race.
- Since the 1970s, genetic data have disproven the concept of biological races.
- Human genetic variation is continuous, not discrete, and predominantly exists within populations.
Purpose of the Study:
- To examine the paradoxical relationship between "race" and genetics.
- To critique the use of genetic variation to explain racial differences in disease.
- To highlight the limitations of using race as a proxy for genetic variation.
Main Methods:
- Analysis of historical and contemporary genetic research on race.
- Critique of the assumptions underlying genetic explanations for racial disparities.
- Exploration of the interplay between genetics, social factors, and health.
Main Results:
- Genetic variation does not align with socially defined racial categories.
- The notion that genetic variation explains disease variation is a form of geneticization.
- Attributing disease variation to race is a form of racialization, exaggerating race's biological significance.
Conclusions:
- Race is not a valid biological construct, and genetic variation does not support it.
- Using race as a proxy for genetic differences obscures the impact of political-economic factors and lived experiences on health.
- Understanding the complex processes of racialization and racism is crucial for addressing health disparities.
More Related Videos
Related Concept Videos
Polygenic Traits
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Incomplete Dominance
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Polygenic Traits
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Inheritance
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...
Genetic Variation
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Genes exist in different versions called alleles, which...

