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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

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Ethnic differences in the impact of advanced maternal age on birth prevalence of Down syndrome

B Khoshnood1, P Pryde, S Wall

  • 1Department of Pediatrics, University of Chicago, Ill., USA.

American Journal of Public Health
|November 15, 2000
PubMed

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.When...
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